Representative Investments*


Zerigo Health, Inc.

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Zerigo Health Inc. has developed the first and only connected phototherapy system, The Zerigo Health Solution, that uses an app on the patient’s own smartphone (iOS or Android) to manage the dose, frequency, and duration of targeted narrowband UVB (NB-UVB) light therapy for the treatment of chronic skin diseases such as psoriasis, vitiligo, and eczema. The System helps to ensure that patients receive the proper doses recommended by the American Academy of Dermatology and Vitiligo Working Group's published treatment protocols. The name Zerigo is derived from the primary disorders the company’s solution treats: eczema, psoriasis and vitiligo.  These conditions affect over 30 million people in the U.S.

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TherOptix

TherOptix is developing novel treatment approaches for anterior and posterior ocular indications.  Leveraging a proprietary, minimally invasive anterior delivery platform, TherOptix seeks to improve treatment outcomes by optimally targeting diseased tissue with effective molecules across a range of indications and molecule classes.


Equinox

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Equinox is a medical device company with an adjustable, non-surgical, non-pharmacological technology to treat diseases of the optic nerve such as glaucoma, idiopathic intracranial hypertension (IIH), hypotony, visual impairment and intracranial pressure (VIIP). The company has been granted two patents with four patents in process. It has also received early funding commitments from leading ophthalmology experts, and a grant from NASA/NSBRI as part of the Vision For Mars program.


Orasis Pharmaceuticals

Orasis is an emerging ophthalmic pharmaceutical company developing a prescription eye drop for presbyopia as an alternative to reading glasses. Presbyopia is the gradual loss of an eye’s ability to focus on near objects, which begins to affect most people sometime after the age of 40 and affects more than 1.8 billion people worldwide.

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Continental Realty Group / CRA

This Denver, Colorado based company has been in the business of acquiring, renovating, owning, operating, and selling multi-family housing complexes nationwide for more than 25 years. Their proprietary system, AIM, allows them to manage the phases of the real estate investment process: Analysis-Investment-Management. Because of their track record and unique due diligence process, Bluestem has participated in a number of investments with this company and has invested in many properties in high growth markets.

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Intelliflux

Adaptive control software utilizing artificial intelligence to improve the performance efficiency of water treatment plants. Quick installation of universal hardware/software bundle provides immediate savings in water and energy with added protection against variable feed water quality. IMPACT: Proven customer demonstrations and early commercial installations highlight up to 30% energy savings in operation of membrane filtration systems.

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VIRUN, INC.

VIRUN, a Nutra-BioSciences® company, has developed over 200 fortified ingredients and finished beverage and supplement products; with over 60 patents and patent applications world-wide, focused on difficult-to-dissolve variants for food, beverage and supplement applications.  The ingredients are associated with health claims, such as: Cardiovascular Health, Energy and Cognitive Function, Weight Management, and Energy. VIRUN has successfully branded its OmegaH2O® Omega-3 EPA DHA, Coenzyme Clear® CoQ10, Esolv®, and DPtechnology® among other water soluble liquid and powder concentrates.

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EDCO

EDCO Health Information Solutions designs, develops and implements software solutions for the health care industry in North America.  EDCO’s Solarity® software provides point of care batch scanning and indexing of patient medical records that complements electronic health record systems.  The end result is an accurate and complete electronic medical record, reduced costs, and improved patient outcomes. For more information visit http://www.solaritybyedco.com/

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neurolens™, Inc. (formerly eyeBrain Medical)

Inspired by a breakthrough discovery linking optometry and neurology, neurolens is unlocking a new dimension of vision care. With patented Contoured Prism technology, neurolenses are the first and only prescription lenses that go beyond visual acuity to provide visual comfort for the nearly 65% of US adults who complain of headaches, neck/shoulder pain and eyestrain when using digital devices, reading or doing detail work. The neurolens Contoured Prism design helps the eyes work together comfortably, bringing the eyes into alignment to relieve painful symptoms. Technology from neurolens is only available to Independent Eye Care Providers.

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Hubble Therapeutics

Hubble Therapeutics (Hubble TX) is a developer of a gene therapy intended for pediatric patients with the retinal blinding disease. The company's proprietary gene therapy is based on an adeno-associated viral (AAV) vector used for Leber Congenital Amaurosis (LCA), a rare genetic eye disorder, thereby pioneering novel ion channel gene therapies to restore vision.

Visit Hubble TX


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Virtual Incision Corporation

Virtual Incision is on a mission to simplify robotic-assisted surgery (RAS), so more patients and their surgeons can access its benefits every day. Headquartered in Lincoln, Nebraska, and holding over two hundred patents and patent applications, the company is developing MIRA, the first-of-its-kind miniature RAS system. Virtual Incision’s goal is to make every operating room RAS-ready. 

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The Prairie Club

The Prairie Club (Destination Golf, LLC) is a semi-private golf resort located in the secluded sandhills of Nebraska, along the edge of the Snake River canyon. Built in 2009 with two distinct 18-hole courses, a unique 10-hole par three course, and a 40,000 square foot lodge, The Prairie Club was quickly received as one of the best in the world, with Links Magazine naming it one of the top ten 36-hole resorts in North America. Today, it has expanded its on-site lodging to 71 rooms, boasts a growing membership of over 400, and attracts avid golfers from all over the world.

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ianTECH

ianTECH delivers a minimally invasive micro-interventional device to treat cataracts in safe and cost-effective manner without heat-generating vibrational energy or expensive electrically powered equipment.

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SYNQ3

This company, founded in 2007, specializes in operational and off-premise efficiencies for managing incoming calls for its restaurant industry customers. For the company’s fifteen national and regional customers, all phone-in-orders or catering calls from around the U.S. are handled at the Colorado Springs, CO headquarters. VIA, their Virtual Intelligent Assistant, enables measurement of guest experience, guest engagement, and order to-call ratios—metrics formerly unmeasurable in the restaurant industry.

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SpringCM

SpringCM is a secure document and contract management platform. Build workflows and enable document collaboration across your entire organization. Because when your documents flow, work flows.

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Hitch Works Inc.

Hitch is a cloud-based skills intelligence and internal talent mobility platform that helps companies become more inclusive, adaptive, and innovative by connecting the right talent with the right tasks based on skills, experiences and career aspirations. Its proprietary AI-powered solution enables upskilling and reskilling, dynamic teaming, democratized career development, and fosters a culture of learning and growth while accelerating productivity and performance.  

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POET

POET, one of the world's largest ethanol producers, is a leader in biorefining through its efficient, vertically integrated approach to production. The 25-year-old company has a production capacity in excess of 1.6 billion gallons of ethanol and 9 billion pounds of high-protein animal feed annually from its network of 27 production facilities. POET also operates a pilot-scale cellulosic bio-ethanol plant, which uses corn cobs, leaves, husk and some stalk as feedstock, and expects to commercialize the process in Emmetsburg, Iowa through its joint venture with DSM.

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TearClear

TearClear Corp. is an early-stage, disruptive eye health technology company focused on developing a safe and reliable means of delivering preservative-free topical ophthalmic drugs from existing preserved, multi-dose systems.

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LENTECHS

LENTECHS, LLC is a privately held, clinical-stage ophthalmic medical device company, focused on developing a new generation of soft, suspended contact lenses. Headquartered in Columbus, Ohio, LENTECHS is backed by a network of investors who are truly committed to revolutionary innovation in contact lenses.

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sight4all, Inc.

OcuDoc, Inc. is a medical diagnostic company based in Columbus, Ohio. The company’s mission is to identify and assist people globally who suffer from impaired vision (including eye misalignment and refractive errors) with an accessible, accurate and low-cost solution.
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Tear Film Innovations

Tear Film Innovations is an early-stage company developing a family of break-through products for the treatment of evaporative dry eye and related syndromes including meibomian gland dysfunction (MGD) and blepharitis

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Sydnexis, Inc.

Sydnexis, Inc. is a privately held clinical stage biopharmaceutical company based in San Diego that is developing a proprietary formulation for decreasing myopic progression in children. Sydnexis recently initiated a Phase 3 study testing its patented eyedrop formulation, SYD-101. Myopia is the most common eye disease in children and has experienced a dramatic increase in prevalence over the last 30 years. Myopia occurs in 30-40% of children in the U.S. and E.U. and recent estimates suggest that number may be closer to 80% in Asia. Once considered a benign refractive condition, myopia, even at low levels, is associated with numerous serious ophthalmic co-morbidities including: myopic macular degeneration, macular choroidal neovascularization, retinal detachment, glaucoma, and blindness. The greater the severity of myopia, the higher the risk of these ophthalmic co-morbidities later in life. Sydnexis was founded in San Diego in 2014 with the goal of developing a proprietary , stable, topical eyedrop to treat the progression of myopia in children.

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Shoulder Innovations, Inc.

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Shoulder Innovations Inc., based in Holland, Mich., is a medical device development company that designs and commercializes innovative products which demonstrate the potential for improved patient care and reduced overall cost to the healthcare system. Leveraging its breakthrough, patented, InSet™ glenoid design, Shoulder Innovations is commercializing a shoulder replacement implant system focused on improving outcomes related to the greatest cause of shoulder replacement failure: glenoid loosening. The InSet™ technology has been shown in multiple peer reviewed publications to significantly reduce glenoid implant micro-motion and simplifies the surgical technique, potentially reducing complications or increasing implant longevity.

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Pivotal Health Solutions

Pivotal Health Solutions, based in Watertown, SD, manufactures and sells products into the chiropractic, massage, therapy, spa and medical industries. Their trusted brands include: Eurotech Tables, ErgoStyle Tables, iTrac Therapy Chair, Custom Craftworks, Touch Essentials, Cloud 9 Medical Gel, SaniCover, VTI Products, Valley Technology, Lyflo Select, Hydrajoint, Relax Right Memory Foam Pillows, OMNI Cervical Relief Pillows and Apollo Cold Laser. The Company also has partnered with Pressure Positive and Teeter.

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The Community Company

The Community Company builds and manages community-driven programs for media companies and global brands.

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Surface Pharmaceuticals

A biopharmaceutical company focused on development and commercialization of innovative therapeutics for ocular diseases.

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